Sex hormones, sex hormone binding globulin, and vertebral fractures in older men.


The association between sex hormones and sex hormone binding globin (SHBG) with vertebral fractures in men is not well studied. In these analyses, we determined whether sex hormones and SHBG were associated with greater likelihood of vertebral fractures in a prospective cohort study of community dwelling older men. We included data from participants in MrOS who had been randomly selected for hormone measurement (N=1463, including 1054 with follow-up data 4.6years later). Major outcomes included prevalent vertebral fracture (semi-quantitative grade≥2, N=140, 9.6%) and new or worsening vertebral fracture (change in SQ grade≥1, N=55, 5.2%). Odds ratios per SD decrease in sex hormones and per SD increase in SHBG were estimated with logistic regression adjusted for potentially confounding factors, including age, bone mineral density, and other sex hormones. Higher SHBG was associated with a greater likelihood of prevalent vertebral fractures (OR: 1.38 per SD increase, 95% CI: 1.11, 1.72). Total estradiol analyzed as a continuous variable was not associated with prevalent vertebral fractures (OR per SD decrease: 0.86, 95% CI: 0.68 to 1.10). Men with total estradiol values ≤17pg/ml had a borderline higher likelihood of prevalent fracture than men with higher values (OR: 1.46, 95% CI: 0.99, 2.16). There was no association between total testosterone and prevalent fracture. In longitudinal analyses, SHBG (OR: 1.42 per SD increase, 95% CI: 1.03, 1.95) was associated with new or worsening vertebral fracture, but there was no association with total estradiol or total testosterone. In conclusion, higher SHBG (but not testosterone or estradiol) is an independent risk factor for vertebral fractures in older men.

DOI: 10.1016/j.bone.2016.01.009

Cite this paper

@article{Cawthon2016SexHS, title={Sex hormones, sex hormone binding globulin, and vertebral fractures in older men.}, author={Peggy Mannen Cawthon and John T Schousboe and Stephanie Litwack Harrison and Kristine E. Ensrud and Dennis Black and Jane A. Cauley and Steve Cummings and Erin S Leblanc and Gail A. Laughlin and Carrie M. Nielson and Augusta Broughton and Deborah M. Kado and Andrew R Hoffman and Sophie A. Jamal and Elizabeth Barrett-Connor and Eric S. Orwoll}, journal={Bone}, year={2016}, volume={84}, pages={271-8} }