Sex hormones and pregnancy in rheumatoid arthritis and systemic lupus erythematosus.

@article{Ostensen1999SexHA,
  title={Sex hormones and pregnancy in rheumatoid arthritis and systemic lupus erythematosus.},
  author={Monika Ostensen},
  journal={Annals of the New York Academy of Sciences},
  year={1999},
  volume={876},
  pages={131-43; discussion 144}
}
  • Monika Ostensen
  • Published 1999 in Annals of the New York Academy of Sciences
Rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) are autoimmune disorders with a preponderance in females. RA and SLE differ in their response to sex hormones. Disease development of RA is mitigated by estrogen and pregnancy whereas SLE tends to flare during pregnancy and in response to estrogen. Pregnancy improves the symptoms of RA in about 75% of pregnant patients, but relapses within six months postpartum in 90% of cases. RA is regarded as a T cell-mediated and TH1 immune… CONTINUE READING

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