Sex hormones and mucosal wound healing

@article{Engeland2009SexHA,
  title={Sex hormones and mucosal wound healing},
  author={Christopher G Engeland and Bahareh Sabzehei and Phillip T. Marucha},
  journal={Brain, Behavior, and Immunity},
  year={2009},
  volume={23},
  pages={629-635}
}
Wound healing studies, which have chiefly examined dermal tissues, have reported a female advantage in healing rates. In contrast, our laboratory recently demonstrated women heal mucosal wounds more slowly than men. We hypothesized sex hormones influence wound healing rates, possibly through their modulating effects on inflammation. This study involved 329 younger subjects aged 18-43 (165 women, 164 men) and 93 older subjects aged 50-88 (60 women, 33 men). A 3.5mm diameter wound was created on… Expand
Sex and Sex Hormones Mediate Wound Healing
TLDR
A plethora of data now indicate estrogens as a primary regulator of cutaneous healing and systemic or topical oestradiol treatment promotes impaired healing, but it is still not understood what effects estrogen treatment has on microbial profiles within a wound and how this differs between males and females. Expand
Is sex a biological variable in corneal wound healing?
TLDR
The data suggest that sex is not a major biological variable during active corneal wound healing in rabbits in vivo, and wounded corneas showed significantly different changes in these parameters compared to the unwounded cornea. Expand
The Emerging Concept of Hormonal Impact on Wound Healing in Feminizing and Masculinizing Genital Surgery
TLDR
The effects of hormones for their known impact on the wound healing cascade are discussed and chromosomal variations exhibited in disorders of sexual development could modify the hormonal environment and the response to hormones during wound healing. Expand
Wound Healing in the Elderly
TLDR
The elderly have increased rates of infection and wound dehiscence, decreases in wound strength, and slower healing times, primarily caused by reductions in re-epithelialization, angiogenesis, macrophage infiltration, and collagen deposition. Expand
Gonadal hormones differently modulate cutaneous wound healing of chronically stressed mice
TLDR
Gender differences contribute to the cutaneous wound healing of chronically stressed mice and androgens contribute toThe stress-induced impairment of the healing of cutaneous wounds but estrogens inhibit it. Expand
The Efficacy of Platelet-rich Plasma Gel and Topical Estradiol Alone or in Combination on Healing of Full-thickness Wounds.
TLDR
PRP gel + estradiol-treatment enhanced healing in full-thickness wounds by reducing the contraction rate with a trend toward accelerating both epithelial migration and the angiogenic response. Expand
Androgen actions in mouse wound healing: Minimal in vivo effects of local antiandrogen delivery
  • Yiwei Wang, U. Simanainen, +5 authors P. Maitz
  • Medicine
  • Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society
  • 2016
TLDR
The role of androgens in female wound healing is defined and a novel electrospun polycaprolactone scaffold wound dressing material is developed to exploit local antiandrogen effects in wound healing, while minimizing off‐target systemic effects. Expand
EFFECT OF ESTROGEN ON THE PROCESS OF WOUND HEALING IN DIABETIC RATS
TLDR
This research finds that estrogen can improve the impaired wound healing of diabetic rats and this effect is related with the rate of wound healing and wound structure. Expand
Acceleration of cutaneous wound healing by brassinosteroids
TLDR
Topical application of brassinosteroids accelerates wound healing by positively modulating inflammatory and reepithelialization phases of the wound repair process, in part by enhancing Akt signaling in the skin at the edges of the wounds and enhancing migration of fibroblasts in the wounded area. Expand
Age-Related Palatal Wound Healing: An Experimental In Vivo Study
TLDR
Reduced initial tissue damage due to decreased and delayed inflammatory response in the old rats ultimately led to faster clinical wound healing compared to the young rats, despite a statistically non-significant lower proliferative response inThe old rats. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 71 REFERENCES
Mucosal wound healing: the roles of age and sex.
HYPOTHESIS It remains unclear whether aging delays wound healing, as past human studies have not adequately controlled for confounding factors such as morbidity and medications. Furthermore, althoughExpand
Topical estrogen accelerates cutaneous wound healing in aged humans associated with an altered inflammatory response.
The effects of intrinsic aging on the cutaneous wound healing process are profound, and the resulting acute and chronic wound morbidity imposes a substantial burden on health services. We haveExpand
Sex steroids and cutaneous wound healing: the contrasting influences of estrogens and androgens
The increased prevalence in the elderly of chronic wound-healing conditions, such as venous and diabetic ulceration, is firmly established. This same population additionally suffers from impairedExpand
Sex steroids and cutaneous wound healing: the contrasting influences of estrogens and androgens
The increased prevalence in the elderly of chronic wound-healing conditions, such as venous and diabetic ulceration, is firmly established. This same population additionally suffers from impairedExpand
Androgen receptor-mediated inhibition of cutaneous wound healing.
Impaired wound healing states in the elderly lead to substantial morbidity, mortality, and a cost to the US Health Services of over $9 billion per annum. In addition to intrinsic aging per se causingExpand
Estrogen accelerates cutaneous wound healing associated with an increase in TGF-β1 levels
The cellular and molecular mechanisms underlying the effects of aging on human cutaneous wound healing are poorly understood, and the possible role of reproductive hormones in this process has neverExpand
Depressive Symptoms Predict Mucosal Wound Healing
Objective: There is mounting evidence that psychosocial stress can delay wound healing, but this literature almost exclusively pertains to dermal wound healing. Many surgical procedures involveExpand
Differential Injury Responses in Oral Mucosal and Cutaneous Wounds
Oral mucosa heals faster than does skin, yet few studies have compared the repair at oral mucosal and cutaneous sites. To determine whether the privileged healing of oral injuries involves aExpand
Estrogen modulates cutaneous wound healing by downregulating macrophage migration inhibitory factor.
Characteristic of both chronic wounds and acute wounds that fail to heal are excessive leukocytosis and reduced matrix deposition. Estrogen is a major regulator of wound repair that can reverseExpand
Influence of sex hormones on the periodontium.
OBJECTIVES Sex hormones have long been considered to play an influential role on periodontal tissues, bone turnover rate, wound healing and periodontal disease progression. The objectives of thisExpand
...
1
2
3
4
5
...