Sex hormones and lipoprotein metabolism.

  title={Sex hormones and lipoprotein metabolism.},
  author={Frank M. Sacks and Brian W. Walsh},
  journal={Current opinion in lipidology},
  volume={5 3},
Previous findings of increased production of large VLDL particles by estrogen have been confirmed in a trial using estrogen-dominant oral contraceptives. Estrogen has been found to have LDL subclass-specific effects and to shift the distribution of apolipoprotein (apo)E from HDL to VLDL. Several recent studies document decreases in lipoprotein (a) [Lp(a)] levels, but the metabolic mechanism is yet unknown. The effects of progestational agents on lipoprotein metabolism remain unclear in view of… CONTINUE READING
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