Sex hormones and gender-related differences: their influence on chronic renal allograft rejection.

@article{Mller1999SexHA,
  title={Sex hormones and gender-related differences: their influence on chronic renal allograft rejection.},
  author={Veronika M{\"u}ller and Attila Szab{\'o} and Ondreij Viklicky and I Gaul and Stefan P{\"o}rtl and Thomas Philipp and Uwe W Heemann},
  journal={Kidney international},
  year={1999},
  volume={55 5},
  pages={2011-20}
}
BACKGROUND Renal hemodynamics and immune responses differ between males and females. Thus, sex hormones and genetically determined gender differences may determine the process of chronic rejection to some extent. METHODS Female (F) or male (M) F344 kidneys were orthotopically transplanted into ovariectomized female Lewis recipients and were treated for 16 weeks with either estradiol, testosterone, or vehicle. RESULTS Testosterone treatment resulted in increased urinary protein excretion… CONTINUE READING

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