Sex hormones and cardiomyopathic phenotype induced by cardiac beta 2-adrenergic receptor overexpression.

@article{Gao2003SexHA,
  title={Sex hormones and cardiomyopathic phenotype induced by cardiac beta 2-adrenergic receptor overexpression.},
  author={Xiao-ming Gao and Alex Agrotis and Dominic J. Autelitano and E. Richard Percy and Elizabeth A. Woodcock and Garry L Jennings and Anthony M Dart and Xiao-jun Du},
  journal={Endocrinology},
  year={2003},
  volume={144 9},
  pages={4097-105}
}
Sex differences in cardiomyopathic phenotype and the role of gonadal status were studied in mice with cardiac overexpression of beta(2)-adrenergic receptors (ARs) over 6-15 months (mo) of age. Survival to 15 mo was 96% in wild-type mice but was poorer in transgenic (TG) mice and lower for males than females (13% vs. 56%, P < 0.001). Echocardiography… CONTINUE READING