Sex hormones, acting on the TERT gene, increase telomerase activity in human primary hematopoietic cells.

  title={Sex hormones, acting on the TERT gene, increase telomerase activity in human primary hematopoietic cells.},
  author={Rodrigo T. Calado and William T Yewdell and Keisha L Wilkerson and Joshua A. Regal and Sachiko Kajigaya and Constantine A Stratakis and Neal S. Young},
  volume={114 11},
Androgens have been used in the treatment of bone marrow failure syndromes without a clear understanding of their mechanism of action. Blood counts of patients with dyskeratosis congenita or aplastic anemia with mutations in telomerase genes can improve with androgen therapy. Here we observed that exposure in vitro of normal peripheral blood lymphocytes and human bone marrow-derived CD34(+) cells to androgens increased telomerase activity, coincident with higher TERT mRNA levels. Cells from… CONTINUE READING


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