Sex hormone replacement therapy for individuals with Turner syndrome

@article{Backeljauw2019SexHR,
  title={Sex hormone replacement therapy for individuals with Turner syndrome},
  author={Philippe F. Backeljauw and Karen O Klein},
  journal={American Journal of Medical Genetics Part C: Seminars in Medical Genetics},
  year={2019},
  volume={181},
  pages={79 - 83}
}
  • P. Backeljauw, K. Klein
  • Published 1 March 2019
  • Medicine, Biology
  • American Journal of Medical Genetics Part C: Seminars in Medical Genetics
Turner syndrome is a relatively common genetic condition resulting from absence of all or part of the second sex chromosome. Individuals with Turner syndrome commonly exhibit cardiovascular, endocrine, renal, reproductive, and/or psychosocial abnormalities, among other conditions. Most girls with Turner syndrome have hypergonadotropic hypogonadism and therefore need sex steroid hormonal replacement therapy. The optimal estrogen replacement treatment regimen to induce pubertal development is… 
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TLDR
The effects of estrogen and androgen insufficiency as well as the effects of sex HRT on morbidity and mortality with special emphasis on evidence based research and areas needing further studies are discussed.
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TLDR
The study shows that growth hormone treatment increases adult height in patients with Turner's syndrome and suggests that combining childhood ultra-low-dose estrogen with growth hormone may improve growth and provide other potential benefits associated with early initiation of estrogen replacement.
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TLDR
It is concluded that using very low doses of systemic estradiol to induce puberty before the age of 15 years in girls with TS who are treated with GH, instead of using routine estrogen therapy, can result in increased final heights.
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TLDR
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TLDR
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TLDR
In addition to previously reported effects on cognitive measures and GH-mediated height gain, childhood estrogen replacement significantly normalized the onset and tempo of puberty.
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TLDR
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TLDR
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TLDR
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  • Medicine, Biology
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TLDR
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