Sex hormone replacement therapy for individuals with Turner syndrome

  title={Sex hormone replacement therapy for individuals with Turner syndrome},
  author={Philippe F. Backeljauw and Karen O Klein},
  journal={American Journal of Medical Genetics Part C: Seminars in Medical Genetics},
  pages={79 - 83}
  • P. Backeljauw, K. Klein
  • Published 1 March 2019
  • Medicine, Biology
  • American Journal of Medical Genetics Part C: Seminars in Medical Genetics
Turner syndrome is a relatively common genetic condition resulting from absence of all or part of the second sex chromosome. Individuals with Turner syndrome commonly exhibit cardiovascular, endocrine, renal, reproductive, and/or psychosocial abnormalities, among other conditions. Most girls with Turner syndrome have hypergonadotropic hypogonadism and therefore need sex steroid hormonal replacement therapy. The optimal estrogen replacement treatment regimen to induce pubertal development is… 
7 Citations
Recognition and management of adults with Turner syndrome: From the transition of adolescence through the senior years
This article focuses on the recognition and management of Turner syndrome from adolescents in transition, through adulthood, and into another transition as older women.
Non-menopausal endocrine and non-endocrine causes of flushing and sweating
This clinical review elaborates on the non-menopausal endocrine and non-endocrine causes of flushing and sweating, including both common and rarer conditions.
Clinical and cytogenetic characteristics of patients diagnosed with Turner syndrome in a clinical genetics service: cross-sectional retrospective study.
It was found that, in general, patients with TS were being diagnosed late, which appeared to be leading to underdiagnosis of many abnormalities.
Endocrine Disorder in Patients With Craniopharyngioma
The latest research progress on pathogenesis, manifestation, significance, and treatment of endocrine disorders in patients with craniopharyngioma is reviewed.
Turner Syndrome


Sex hormone replacement in Turner syndrome
The effects of estrogen and androgen insufficiency as well as the effects of sex HRT on morbidity and mortality with special emphasis on evidence based research and areas needing further studies are discussed.
Growth hormone plus childhood low-dose estrogen in Turner's syndrome.
The study shows that growth hormone treatment increases adult height in patients with Turner's syndrome and suggests that combining childhood ultra-low-dose estrogen with growth hormone may improve growth and provide other potential benefits associated with early initiation of estrogen replacement.
Optimizing estrogen replacement treatment in Turner syndrome.
It is concluded that using very low doses of systemic estradiol to induce puberty before the age of 15 years in girls with TS who are treated with GH, instead of using routine estrogen therapy, can result in increased final heights.
Use of percutaneous estrogen gel for induction of puberty in girls with Turner syndrome.
With percutaneous estradiol gel, the development of secondary sexual characteristics and uterine growth proceeded gradually, mimicking natural puberty, and Estradiol gel provides an excellent way to individualize pubertal induction.
Hormone replacement therapy may improve hepatic function in women with Turner's syndrome
Assessment of hepatic function in women with Turner's syndrome and the effect of oral oestradiol valerate on liver enzymes found that oestrogen replacement therapy may exacerbate hepatic dysfunction.
Effects of low-dose estrogen replacement during childhood on pubertal development and gonadotropin concentrations in patients with Turner syndrome: results of a randomized, double-blind, placebo-controlled clinical trial.
In addition to previously reported effects on cognitive measures and GH-mediated height gain, childhood estrogen replacement significantly normalized the onset and tempo of puberty.
Conjugated oral versus transdermal estrogen replacement in girls with Turner syndrome: a pilot comparative study.
In girls with TS, TD E2 resulted in faster bone accrual at the spine and increased uterine growth compared with conjugated oral estrogen and this pilot study provides preliminary information for optimizing estrogen replacement in this population.
Metabolic effects of oral versus transdermal estrogen in growth hormone-treated girls with turner syndrome.
Data suggest that the route of delivery of estrogen does not adversely affect these metabolic effects of GH in young girls with Turner syndrome, and neither oral nor TD estrogen adversely affected rates of protein turnover, lipolysis, and lipid oxidation rates or plasma lipids, fibrinogen, or fasting insulin concentrations.
Puberty induction in Turner syndrome: results of oestrogen treatment on development of secondary sexual characteristics, uterine dimensions and serum hormone levels
A large number of girls with Turner syndrome are diagnosed with gonadal dysgenesis leading to a lack of oestrogen, which is one of the main characteristics of Turner syndrome.
Physiologic estrogen replacement increases bone density in adolescent girls with anorexia nervosa
  • M. Misra, D. Katzman, A. Klibanski
  • Medicine, Biology
    Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
  • 2011
It is concluded that physiologic estradiol replacement increases spine and hip BMD in girls with AN, even after controlling for baseline age and weight.