Sex hormone-binding globulin mediates steroid hormone signal transduction at the plasma membrane

  title={Sex hormone-binding globulin mediates steroid hormone signal transduction at the plasma membrane},
  author={William Rosner and Daniel J. Hryb and M. Saeed Khan and Atif M. Nakhla and Nicholas A. Romas},
  journal={The Journal of Steroid Biochemistry and Molecular Biology},
  • W. Rosner, D. Hryb, N. Romas
  • Published 1 April 1999
  • Biology, Medicine
  • The Journal of Steroid Biochemistry and Molecular Biology
Diverse Roles for Sex Hormone-Binding Globulin in Reproduction1
This review compares the production and functions of sex hormone-binding globulin in different species and evaluates the diverse effects this has on reproduction.
Sex steroid hormone receptors, their ligands, and nuclear and non-nuclear pathways
Recent work has demonstrated new pathways of steroid signaling through orphan and cell surface receptors that contribute to more rapid, “non-nuclear” or non-transcriptional effects of steroid hormones, often involving G-protein-mediated pathways.
The roles of androgen receptors and androgen-binding proteins in nongenomic androgen actions.
The biological activity of testosterone and dihydrotestosterone is thought to occur predominantly through binding to the androgen receptor (AR), a member of the nuclear receptor superfamily that
Steroid-hormone rapid actions, membrane receptors and a conformational ensemble model
This review summarizes the current knowledge of membrane-associated steroid receptors, as well as details of structure–function relationships between steroid hormones and the ligand-binding domains of their nuclear and membrane- associated receptors.
Role of Endocytosis in Cellular Uptake of Sex Steroids
Sex hormone-binding globulin and heart failure: a passive carrier of steroid hormones or an active hormone itself?
Rapid actions of androgens
[Molecular actions of 17β-estradiol and progesterone and their relationship with cellular signaling pathways].
This review provides a comprehensive insight into the molecular actions of 17β-estradiol and progesterone, aiming to present the role of these sex steroids in regulation of cellular signaling pathways.


The control of the interaction of sex hormone-binding globulin with its receptor by steroid hormones.
Stimulation of prostate cancer growth by androgens and estrogens through the intermediacy of sex hormone-binding globulin.
It is concluded that cAMP causes increased growth in this prostate cancer cell line, and that both SH BG-dihydrotestosterone and SHBG-estradiol can regulate intracellular cAMP, and hence growth, in these cells.
Molecular properties of corticosteroid binding globulin and the sex-steroid binding proteins.
This review will concentrate on the molecular properties of two other biologically important classes of extracellular steroid binding proteins: corticosteroid binding globulin (CBG) and the sex-steroid binding proteins; sex hormone binding Globulin (SHBG) and androgen binding protein...
Estradiol Activates the Prostate Androgen Receptor and Prostate-specific Antigen Secretion through the Intermediacy of Sex Hormone-binding Globulin*
There is a signaling system that amalgamates steroid-initiated intracellular events with steroid-dependent occurrences generated at the cell membrane and that the latter signaling system proceeds by a pathway that involves protein kinase A.
Biologically active steroids activate receptor-bound human sex hormone-binding globulin to cause LNCaP cells to accumulate adenosine 3',5'-monophosphate.
The binding of human sex hormone-binding globulin to a human prostatic cancer cell line (LNCaP) and the results of that binding were examined and demonstrate an additional mode of action of steroid hormones, one that does not require that the steroid interact with a steroid receptor.
An alternative ligand-independent pathway for activation of steroid receptors.
The functions of corticosteroid-binding globulin and sex hormone-binding globulin: recent advances.
  • W. Rosner
  • Biology, Medicine
    Endocrine reviews
  • 1990
In the interval since their discovery, sophisticated binding and RIAs have been devised for their measurement, and yet they have been the subject of two long, splendid monographs and many shorter reviews.
The membrane receptor for sex steroid binding protein is not ubiquitous
The tissue distribution of the membrane receptor for the Sex Steroid Binding Protein (SBP) has been studied, either in estrogen/androgen dependent tissues and in tissues not strictly sex steroid
Sex steroid binding protein exerts a negative control on estradiol action in MCF-7 cells (human breast cancer) through cyclic adenosine 3',5'-monophosphate and protein kinase A.
The present study strongly confirms the previous observation that SBP inhibits the estradiol induction of MCF-7 cell growth, appropriately suggesting that this SBP action, a consequence of the interaction with the receptor, is likely to be mediated by cAMP and PKA.