Sex hormone-binding globulin mediates steroid hormone signal transduction at the plasma membrane

@article{Rosner1999SexHG,
  title={Sex hormone-binding globulin mediates steroid hormone signal transduction at the plasma membrane},
  author={W. Rosner and D. Hryb and M. Khan and A. M. Nakhla and N. Romas},
  journal={The Journal of Steroid Biochemistry and Molecular Biology},
  year={1999},
  volume={69},
  pages={481-485}
}
  • W. Rosner, D. Hryb, +2 authors N. Romas
  • Published 1999
  • Biology, Medicine
  • The Journal of Steroid Biochemistry and Molecular Biology
Sex hormone-binding globulin is a plasma glycoprotein that binds certain estrogens and androgens with high affinity. Over the past several years it has been shown that, in addition to functioning as a regulator of the free concentration of a number of steroid hormones, SHBG plays a central role in permitting certain steroid hormones to act without entering the cell. The system is complex. SHBG interacts with a specific, high affinity receptor (R(SHBG)) on cell membranes that appears to… Expand
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