Sex hormone-binding globulin and type 2 diabetes mellitus

  title={Sex hormone-binding globulin and type 2 diabetes mellitus},
  author={Trang Nha Le and John Edwin Nestler and Jerome F Strauss and Edmond P. Wickham},
  journal={Trends in Endocrinology & Metabolism},
Sex hormone-binding globulin (SHBG) has emerged as one of the multiple genetic and environmental factors that potentially contribute to the pathophysiology of type 2 diabetes mellitus (T2DM). In addition to epidemiologic studies demonstrating a consistent relationship between decreased levels of serum SHBG and incident T2DM, recent genetic studies also reveal that transmission of specific polymorphisms in the SHBG gene influence the risk of T2DM. At the molecular level, the multiple… CONTINUE READING
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