Sex-dimorphic changes in neuroactive steroid levels after chronic experimental autoimmune encephalomyelitis.

@article{Caruso2010SexdimorphicCI,
  title={Sex-dimorphic changes in neuroactive steroid levels after chronic experimental autoimmune encephalomyelitis.},
  author={Donatella Caruso and Giulia D'Intino and Silvia Giatti and Omar Maschi and Marzia Pesaresi and Donato Calabrese and Luis-Miguel Garcia-Segura and Laura Calz{\`a} and Roberto Cosimo Melcangi},
  journal={Journal of neurochemistry},
  year={2010},
  volume={114 3},
  pages={921-32}
}
Our previous observations have shown that neuroactive steroid levels in the brain are affected by acute experimental autoimmune encephalomyelitis (EAE) with sex and regional specificity (Giatti et al. 2010). To better understand the effect of EAE on neuroactive steroids, we have here assessed the levels of pregnenolone, progesterone and its derivatives (i.e. dihydroprogesterone, tetrahydroprogesterone and isopregnanolone), testosterone and its derivatives (dihydrotestosterone and 5alpha… CONTINUE READING
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