Sex differences in voluntary oral nicotine consumption by adolescent mice: a dose-response experiment.

@article{Klein2004SexDI,
  title={Sex differences in voluntary oral nicotine consumption by adolescent mice: a dose-response experiment.},
  author={Laura Cousino Klein and Michele McClellan Stine and David J. Vandenbergh and Courtney A. Whetzel and Helen M Kamens},
  journal={Pharmacology, biochemistry, and behavior},
  year={2004},
  volume={78 1},
  pages={13-25}
}
Recent studies with adolescent rodents offer valuable information regarding the neurochemical and behavioral effects of adolescent nicotine exposure. One hundred twenty-one male and 125 female adolescent (35 days of age) C57BL/6J mice were tested for voluntary nicotine consumption by providing 24-h access to both saccharin-only (SAC) and one of six nicotine-containing solutions [10, 25, 50, 75, 100, 200 ug (-)-freebase nicotine/ml in 2% SAC] in the home cage for 7 days. Although males and… CONTINUE READING

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