Sex differences in tuberculosis

@article{Hertz2018SexDI,
  title={Sex differences in tuberculosis},
  author={David Hertz and Bianca Schneider},
  journal={Seminars in Immunopathology},
  year={2018},
  volume={41},
  pages={225-237}
}
Tuberculosis is the most prevalent bacterial infectious disease in humans and the leading cause of death from a single infectious agent, ranking above HIV/AIDS. The causative agent, Mycobacterium tuberculosis, is carried by an estimated two billion people globally and claims more than 1.5 million lives each year. Tuberculosis rates are significantly higher in men than in women, reflected by a male-to-female ratio for worldwide case notifications of 1.7. This phenomenon is not new and has been… 
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54 Citations
Background Citations
21
Methods Citations
1
Results Citations
3

54 Citations

Tuberculosis and Gender in Nigeria, Sex Differences in Diagnosis and Treatment Outcome of TB and TB HIV Infected Patients
TLDR
More TB cases in males but females are more prone to TB HIV confection, have better treatment outcome and lower default rate, and gender-specific strategies are warranted to optimize TB management.
Analysis of extrapulmonary tuberculosis in Spain: 2007-2012 National Study.
Missing men with tuberculosis: the need to address structural influences and implement targeted and multidimensional interventions
TLDR
Debates and the limited available empirical literature on men’s engagement with TB-related healthcare are nevertheless indicating need for a shift, within TB work with men in high burden LMICs towards, structural and multicomponent interventions.
The second national tuberculosis prevalence survey in Vietnam
TLDR
The results indicate that improving TB diagnostic capacity and access to care, along with reducing TB stigma, need to be top priorities for TB control and elimination in Vietnam.
Prevalence of mycobacterium tuberculosis and their possible risk factors in suspected tuberculosis patients of district mardan khyber pakhtunkhwa, Pakistan
TLDR
Infection by M. tuberculosis is frequently spread from infected tuberculosis patients to other persons by aerosolized droplet nuclei which are generated during coughing, speaking, laughing sneezing and shouting.
Increased male susceptibility to Mycobacterium tuberculosis infection is associated with smaller B cell follicles in the lungs
TLDR
This study reveals sex differences in the formation of B cell follicles in the Mtb infected lung and proposes that impaired follicle formation is responsible for accelerated disease progression in males.
Epidemiological profile among pulmonary and extrapulmonary tuberculosis patients in Laayoune, Morocco
TLDR
Results obtained in tuberculosis patients in Laayoune, Morocco showed that active tuberculosis was associated with risk factors such as sex, age and smoking.
Tuberculosis Infection in Women of Reproductive Age: A Cross-sectional Study at Antenatal Care Clinics in an Ethiopian City
TLDR
TB infection in women of reproductive age in Ethiopia was independently associated with HIV infection and increasing age, suggesting exposure to contagious TB and continuous acquisition of TB infection in this population.
Sex-Dependent Differential Expression of Lipidic Mediators Associated with Inflammation Resolution in Patients with Pulmonary Tuberculosis
TLDR
Men are the major contributors to the typical pro-inflammatory profile observed in the serum of tuberculosis patients, and RvD1 plays a vital role in resolving the inflammatory process of TB in women.
Identification and Prediction of Tuberculosis in Eastern China: Analyses from 10-year Population-based Notification Data in Zhejiang Province, China
TLDR
Results from the rate difference (RD) analysis showed that the rising TB incidence mainly presented in the young group of “15–20” and elder group of“65–70”, implying that some implementations such as the increased frequency of checkup in specific student groups and strengthening of elder health examination could be explored and integrated into available health policy.
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