Sex differences in the regulation of progesterone receptor isoforms expression in the rat brain.

@article{GuerraAraiza2002SexDI,
  title={Sex differences in the regulation of progesterone receptor isoforms expression in the rat brain.},
  author={Christian Guerra-Araiza and Ang{\'e}lica Coyoy-Salgado and Ignacio Camacho-Arroyo},
  journal={Brain research bulletin},
  year={2002},
  volume={59 2},
  pages={105-9}
}
We studied the effects of estradiol (E2) and progesterone (P) on progesterone receptor (PR) isoforms gene expression in the brain of ovariectomised female and gonadectomised male rats by RT-PCR analysis. In female rats, the expression of both PR isoforms was induced by E2 and down-regulated by P in the hypothalamus, whereas in the preoptic area these changes were only observed in PR-B isoform. On the contrary, in the hippocampus and the olfactory bulb, PR-A was the isoform induced by E2. In… CONTINUE READING