Sex differences in the multiple-dose streptozotocin model of diabetes.

  title={Sex differences in the multiple-dose streptozotocin model of diabetes.},
  author={Aldo A. Rossini and R. Michael Williams and Michael C. Appel and A. A. Like},
  volume={103 4},
The hyperglycemic response to multiple low-dose SZ injections was measured in castrated and non-castrated male and female mice with or without testosterone treatment. On the 10th day of the experiment, control males had plasma glucose concentrations that were significantly higher than those of control females. Castration of males decreased the hyperglycemic response, while testosterone treatment restored it. The glucose concentrations in castrated females were significantly greater than control… CONTINUE READING

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