Sex differences in the generalization of fear as a function of retention intervals.

@article{Lynch2013SexDI,
  title={Sex differences in the generalization of fear as a function of retention intervals.},
  author={Joseph F. Lynch and Patrick K. Cullen and Aaron M. Jasnow and David C. Riccio},
  journal={Learning & memory},
  year={2013},
  volume={20 11},
  pages={628-32}
}
In previous studies using male rodents, context change disrupted a fear response at a short, but not a long, retention interval. Here, we examined the effects of context changes on fear responses as a function of time in male and female rats. Males displayed context discrimination at all intervals, whereas females exhibited generalization by 5 d. Ovariectomized females with no hormone replacement displayed context discrimination at 5 d, whereas those receiving 17β-estradiol generalized their… CONTINUE READING

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