Sex differences in the effect of finasteride on acute ethanol withdrawal severity in C57BL/6J and DBA/2J mice

@article{GorinMeyer2007SexDI,
  title={Sex differences in the effect of finasteride on acute ethanol withdrawal severity in C57BL/6J and DBA/2J mice},
  author={R. E. Gorin-Meyer and K. Wiren and M. Tanchuck and S. Long and D. Finn},
  journal={Neuroscience},
  year={2007},
  volume={146},
  pages={1302-1315}
}
  • R. E. Gorin-Meyer, K. Wiren, +2 authors D. Finn
  • Published 2007
  • Chemistry, Medicine
  • Neuroscience
  • The neurosteroid allopregnanolone (ALLO) is a potent positive modulator of GABAA receptors that can modulate ethanol (EtOH) withdrawal. The 5alpha-reductase inhibitor finasteride can block the formation of ALLO and other GABAergic neurosteroids and also reduce certain effects of EtOH. Treatment with finasteride during chronic EtOH exposure decreased EtOH withdrawal severity and blood EtOH concentrations (BECs), suggesting an additional effect of finasteride on EtOH pharmacokinetics. Thus, the… CONTINUE READING
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