Sex differences in risk of lung cancer associated with methylene-tetrahydrofolate reductase polymorphisms.

@article{Shi2005SexDI,
  title={Sex differences in risk of lung cancer associated with methylene-tetrahydrofolate reductase polymorphisms.},
  author={Qiuling Shi and Zhendong Zhang and Guojun Li and Patricia C. Pillow and L. M. Malanco Hern{\'a}ndez and Margaret R. Spitz and Qingyi Wei},
  journal={Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology},
  year={2005},
  volume={14 6},
  pages={1477-84}
}
Methylenetetrahydrofolate reductase (MTHFR) catalyzes the metabolism of folate and nucleotides needed for DNA synthesis and repair. Variations in MTHFR functions likely play roles in the etiology of lung cancer. The MTHFR gene has three nonsynonymous single nucleotide polymorphisms (i.e., C677T, A1298C, and G1793A) that have a minor allele frequency of >5%. We investigated the associations between the frequencies of MTHFR variant genotypes and risk of lung cancer in a hospital-based case… CONTINUE READING
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