Sex differences in response to chronic mild stress and congenital serotonin deficiency

@article{Sachs2014SexDI,
  title={Sex differences in response to chronic mild stress and congenital serotonin deficiency},
  author={Benjamin D. Sachs and Jason R. Ni and Marc G. Caron},
  journal={Psychoneuroendocrinology},
  year={2014},
  volume={40},
  pages={123-129}
}
Women exhibit a nearly twofold increased risk of developing depression and anxiety disorders when compared to men, a fact that has been hypothesized to result in part from increased stress susceptibility. Here, we used the tryptophan hydroxylase-2 R439H knock-in mouse (Tph2KI) and the chronic unpredictable mild stress (CMS) model to examine sex differences in response to congenital 5-HT deficiency and chronic stress. Our results demonstrate that female mice, but not 5-HT-deficient animals… CONTINUE READING
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