Sex differences in platelet toll-like receptors and their association with cardiovascular risk factors.

@article{Koupenova2015SexDI,
  title={Sex differences in platelet toll-like receptors and their association with cardiovascular risk factors.},
  author={Milka Koupenova and Eric O. Mick and Ekaterina Mikhalev and Emelia J Benjamin and Kahraman Tanriverdi and Jonathan E. Freedman},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  year={2015},
  volume={35 4},
  pages={
          1030-7
        }
}
OBJECTIVE Platelets contribute to thrombosis, and platelet toll-like receptors (TLRs) are central in pathogen detection, potentially mediating infection-induced vascular occlusion. Using a large community-based cohort study, we sought to examine if platelets express all known TLR transcripts and analyze their association with cardiovascular risk factors. APPROACH AND RESULTS mRNA levels for TLRs were measured in isolated platelets by high-throughput quantitative reverse transcriptase… CONTINUE READING

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