Sex differences in plasma cocaine levels and subjective effects after acute cocaine administration in human volunteers

@article{Lukas1996SexDI,
  title={Sex differences in plasma cocaine levels and subjective effects after acute cocaine administration in human volunteers},
  author={Scott E. Lukas and Michelle B Sholar and Leslie H. Lundahl and Xavier Lamas and Efi Kouri and James D Wines and L. Kragie and Jack H. Mendelson},
  journal={Psychopharmacology},
  year={1996},
  volume={125},
  pages={346-354}
}
Gender differences after acute cocaine administration have received little attention in spite of the fact that males and females respond differently to many drugs. Seven male and seven female occasional cocaine users received both an intranasal dose of cocaine hydrochloride (0.9 mg/kg) and placebo powder in a randomized order and reported subjective effects via an instrumental joystick device and various questionnaires. Blood samples were withdrawn at 5-min intervals to assess pharmacokinetic… CONTINUE READING