Sex differences in physical dependence on pentobarbital in four inbred strains of rats.

@article{Suzuki1992SexDI,
  title={Sex differences in physical dependence on pentobarbital in four inbred strains of rats.},
  author={Tsutomu Suzuki and Yasunori Koike and Saizo Yanaura and Frank R. George and R A Meisch},
  journal={General pharmacology},
  year={1992},
  volume={23 3},
  pages={487-92}
}
1. In Lewis (LEW), Fischer 344 (F344), Spontaneously hypertensive (SHR) and Wistar Kyoto (WKY) rats, pentobarbital (PB)-induced sleep time was much longer in female than in male rats. 2. At the time of awakening, brain levels of PB were significantly higher in the female F344 than in the male rats, but there was no sex differences in other strains. 3. Each… CONTINUE READING