Sex differences in opioid analgesia: "from mouse to man".

  title={Sex differences in opioid analgesia: "from mouse to man".},
  author={Rebecca M Craft},
  journal={The Clinical journal of pain},
  volume={19 3},
BACKGROUND Numerous experimental studies, conducted primarily over the past 10 years, show that there are sex differences in opioid analgesia. This review summarizes the published literature on sex differences in analgesia produced by acute administration of drugs acting at mu-, kappa-, and delta-opioid receptors, in animals and humans. Additionally, methodological issues in research into opioid sex differences are discussed. CONCLUSIONS Procedural variables that may influence the outcome of… CONTINUE READING


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