Sex differences in myocardial contractility in the rat

  title={Sex differences in myocardial contractility in the rat},
  author={Joseph M. Capasso and R. M. Remily and Robert H. Smith and E. H. Sonnenlick},
  journal={Basic Research in Cardiology},
We examined the intrinsic contractile performance of papillary muscles removed from the left ventricle of male and female Wistar rats. Muscles were studied isometrically and isotonically, stimulated at 0.1 Hz, perfused with Tyrode's solution having an external calcium concentration=2.4 and maintained at 30°C. In addition, we examined muscle response to changes in external calcium, added norepinephrine or verapamil and alterations in contraction frequency. No significant change in peak isometric… CONTINUE READING


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