Sex differences in morphine analgesia: an experimental study in healthy volunteers.

  title={Sex differences in morphine analgesia: an experimental study in healthy volunteers.},
  author={Elise Y. Sarton and Erik Olofsen and Raymonda R Romberg and Jan C den Hartigh and Benjamin Kest and Diederik J F Nieuwenhuijs and Anton G L Burm and Luc J Teppema and Albert Dahan},
  volume={93 5},
  pages={1245-54; discussion 6A}
BACKGROUND Animal and human studies indicate the existence of important sex-related differences in opioid-mediated behavior. In this study the authors examined the influence of morphine on experimentally induced pain in healthy male and female volunteers. METHODS Young healthy men and women (10 of each sex) received intravenous morphine (bolus 0.1-mg/kg dose followed by an infusion of 0.030 mg. kg-1. h-1 for 1 h). Pain threshold and pain tolerance in response to a gradual increase in… CONTINUE READING

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