Sex differences in hepatic heme oxygenase expression and activity following trauma and hemorrhagic shock.

@article{Toth2003SexDI,
  title={Sex differences in hepatic heme oxygenase expression and activity following trauma and hemorrhagic shock.},
  author={Balazs Toth and Yukihiro Yokoyama and Joachim F. Kuebler and Martin G. Schwacha and Loring W. Rue and Kirby I. Bland and Irshad H. Chaudry},
  journal={Archives of surgery},
  year={2003},
  volume={138 12},
  pages={1375-82}
}
HYPOTHESIS Sex differentially influences heme oxygenase (HO) expression following trauma and hemorrhagic shock. DESIGN Prospective controlled animal study. SETTING A university laboratory. INTERVENTIONS Female Sprague-Dawley rats in the proestrus stage of their estrus cycle and male rats underwent a 5-cm midline laparotomy (ie, induction of soft tissue trauma) and were bled to a mean arterial blood pressure of 35 mm Hg for approximately 90 minutes, after which they were resuscitated with… CONTINUE READING
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