Sex differences in corticotropin-releasing factor signaling and trafficking

  title={Sex differences in corticotropin-releasing factor signaling and trafficking},
  author={Debra A. Bangasser and A Curtis and Beverly A. S. Reyes and Thelma T. Bethea and Ioannis Parastatidis and Harry Ischiropoulos and Elisabeth J. Van Bockstaele and Rita J Valentino},
  journal={Molecular Psychiatry},
This schematic illustrates sex differences in corticotropin-releasing factor receptor (CRFr) function. CRFr coupling to the GTP-binding protein, Gs is greater in the female compared to the male neuron, an effect that can result in increased cellular signaling in response to stress in females. In the male neuron (right) stress induces CRFr association with b-arrestin2 and subsequent receptor internalization into endosomes (yellow). Internalized receptors can be trafficked back the membrane or… CONTINUE READING