Sex differences in contextual fear conditioning are associated with differential ventral hippocampal extracellular signal-regulated kinase activation.

@article{Gresack2009SexDI,
  title={Sex differences in contextual fear conditioning are associated with differential ventral hippocampal extracellular signal-regulated kinase activation.},
  author={Jodi E. Gresack and Glenn E. Schafe and Patrick T Orr and Karyn M. Frick},
  journal={Neuroscience},
  year={2009},
  volume={159 2},
  pages={451-67}
}
Although sex differences have been reported in hippocampal-dependent learning and memory, including contextual fear memories, the underlying molecular mechanisms contributing to such differences are not well understood. The present study examined the extent to which sex differences in contextual fear conditioning are related to differential activation of the extracellular signal-regulated kinase/mitogen-activated protein kinase (ERK/MAPK), a protein kinase critically involved in memory… CONTINUE READING

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