Sex differences in clinical presentation and response in panic disorder: pooled data from sertraline treatment studies

@article{Clayton2005SexDI,
  title={Sex differences in clinical presentation and response in panic disorder: pooled data from sertraline treatment studies},
  author={Anita H. Clayton and Robert Scott Stewart and Rana S. Fayyad and Cathryn M. Clary},
  journal={Archives of Women's Mental Health},
  year={2005},
  volume={9},
  pages={151-157}
}
SummaryObjective. Gender differences in clinical presentation and response to sertraline treatment were examined for patients diagnosed with DSM-III-R panic disorder with or without agoraphobia. Method. Data was pooled from 4 double-blind, placebo-controlled outpatient studies (males, N = 335; females, N = 338). Two were 12-week fixed-dose studies (sertraline 50 mg vs. 100 mg vs. 200 mg) and 2 were 10-week flexible-dose studies (sertraline 50–200 mg). Primary outcome measures consisted of the… 
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References

SHOWING 1-10 OF 39 REFERENCES
Sertraline treatment of panic disorder: response in patients at risk for poor outcome.
TLDR
Treatment of panic disorder with sertraline was generally effective, even in the presence of baseline clinical variables that have been associated with poor treatment response.
Sertraline in the treatment of panic disorder: a flexible-dose multicenter trial.
TLDR
Results support the safety and efficacy of sertraline for the short-term treatment of patients with panic disorder.
Sertraline in the treatment of panic disorder
TLDR
Sertraline was effective and safe in reducing panic attacks and dry mouth and ejaculation failure (primarily ejaculation delay) were associated significantly with sERTraline.
Sertraline in the treatment of panic disorder: a double-blind multicenter trial.
TLDR
Sertraline is an effective and well-tolerated treatment for patients with panic disorder and had significantly more improvement than placebo in scores on the Quality of Life Enjoyment and Satisfaction Questionnaire and Clinical Global Impression severity of illness and global improvement scales.
The efficacy of sertraline in panic disorder: combined results from two fixed‐dose studies
TLDR
Sertraline was well‐tolerated at all dose levels, with no significant between‐dose differences in patients discontinuing due to adverse events, and the presence of mild‐to‐moderate subsyndromic levels of depression did not reduce the anti‐panic efficacy of sertralines.
Is the course of panic disorder the same in women and men?
TLDR
It is shown that not only are women more likely to have panic with concurrent agoraphobia, but they are more likely than men to suffer a recurrence of panic symptoms after remission of panic.
Double-blind, fixed-dose, placebo-controlled study of paroxetine in the treatment of panic disorder.
TLDR
The minimum dose demonstrated to be significantly superior to placebo was 40 mg/day, although some patients did respond at lower doses, and paroxetine is an effective and well-tolerated short-term treatment of panic disorder.
A comparison of paroxetine, clomipramine and placebo in the treatment of panic disorder
TLDR
Paroxetine produced significant improvements compared with placebo in various measurements of panic attack frequency, and was as effective as clomipramine, but appeared to have a more rapid onset of action than clomIPramine in reducing the number of panic attacks to zero.
Clinical features in panic disorder with agoraphobia: a comparison of men and women.
Outcome of panic disorder. Relationship to diagnostic subtypes and comorbidity.
TLDR
It is shown that while panic disorder has a favorable outcome, the illness is a chronic one that may require continuing treatment and that subtypes and comorbid disturbances are important predictors of outcome.
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