Sex differences in circulating and renal angiotensins of hypertensive mRen(2). Lewis but not normotensive Lewis rats.

@article{Pendergrass2008SexDI,
  title={Sex differences in circulating and renal angiotensins of hypertensive mRen(2). Lewis but not normotensive Lewis rats.},
  author={Karl D. Pendergrass and Nancy T. Pirro and Brian M. Westwood and Carlos Maria Ferrario and K. Bridget Brosnihan and Mark C. Chappell},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2008},
  volume={295 1},
  pages={H10-20}
}
Sex differences in blood pressure are evident in experimental models and human subjects, yet the mechanisms underlying this disparity remain equivocal. The current study sought to define the extent of male-female differences in the circulating and tissue renin-angiotensin aldosterone systems (RAASs) of congenic mRen(2). Lewis and control Lewis rats. Male congenics exhibited higher systolic blood pressure than females [200 +/- 4 vs. 146 +/- 7 mmHg, P < 0.01] or Lewis males and females [113 +/- 2… CONTINUE READING

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