Sex differences in basal and cocaine-induced alterations in PKA and CREB proteins in the nucleus accumbens

@article{Nazarian2008SexDI,
  title={Sex differences in basal and cocaine-induced alterations in PKA and CREB proteins in the nucleus accumbens},
  author={Arbi Nazarian and Wei-Lun Sun and Luyi Zhou and Lynne M. Kemen and Shirzad Jenab and Vanya Qui{\~n}ones-Jenab},
  journal={Psychopharmacology},
  year={2008},
  volume={203},
  pages={641-650}
}
IntroductionAlterations in protein kinase (PKA) protein levels have been implicated in the regulation of responses to and development of cocaine addiction. However, the contribution of differences in PKA intracellular cascade to the known sex differences in responses to cocaine is not well understood. This study examined whether there are intrinsic or cocaine-induced alterations in PKA-mediated responses, such as phosphorylation of cyclic AMP response element binding protein, in male and female… Expand
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