Sex differences in autoimmune disease from a pathological perspective.

@article{Fairweather2008SexDI,
  title={Sex differences in autoimmune disease from a pathological perspective.},
  author={DeLisa Fairweather and Sylvia Frisancho-Kiss and Noel R. Rose},
  journal={The American journal of pathology},
  year={2008},
  volume={173 3},
  pages={
          600-9
        }
}
Autoimmune diseases affect approximately 8% of the population, 78% of whom are women. The reason for the high prevalence in women is unclear. Women are known to respond to infection, vaccination, and trauma with increased antibody production and a more T helper (Th)2-predominant immune response, whereas a Th1 response and inflammation are usually more severe in men. This review discusses the distribution of autoimmune diseases based on sex and age, showing that autoimmune diseases progress from… CONTINUE READING

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