Sex differences in analgesia: a randomized trial of mu versus kappa opioid agonists.

@article{Miller2004SexDI,
  title={Sex differences in analgesia: a randomized trial of mu versus kappa opioid agonists.},
  author={Penny L Miller and Amy A. Ernst},
  journal={Southern medical journal},
  year={2004},
  volume={97 1},
  pages={35-41}
}
OBJECTIVES We sought to evaluate whether there is a sex difference in the analgesic response to mu versus kappa opioids in the management of acute moderate to severe pain of injury in the emergency department. METHODS The study was a randomized, double-blind, clinical trial comparing the prototypical mu-receptor agonist, morphine sulfate, to the prototypical kappa agonist, butorphanol. The primary endpoints were degree of relief by visual analog scores at 30 and 60 minutes. Statistical… CONTINUE READING

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