Sex differences in activation of the hypothalamic-pituitary-adrenal axis by methamphetamine.

@article{Zuloaga2014SexDI,
  title={Sex differences in activation of the hypothalamic-pituitary-adrenal axis by methamphetamine.},
  author={Damian G. Zuloaga and Lance A. Johnson and Maayan Agam and Jacob Raber},
  journal={Journal of neurochemistry},
  year={2014},
  volume={129 3},
  pages={495-508}
}
Dysregulation of hypothalamic-pituitary-adrenal (HPA) axis activation is associated with changes in addiction-related behaviors. In this study, we tested whether sex differences in the acute effects of methamphetamine (MA) exposure involve differential activation of the HPA axis. Male and female mice were injected with MA (1 mg/kg) or saline for comparison of plasma corticosterone and analysis of the immediate early gene c-Fos in brain. There was a prolonged elevation in corticosterone levels… CONTINUE READING
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