Sex differences in NMDA receptor expression in human alcoholics.

  title={Sex differences in NMDA receptor expression in human alcoholics.},
  author={Justin P. Ridge and Ada M-C Ho and Peter Ronald Dodd},
  journal={Alcohol and alcoholism},
  volume={44 6},
AIM The aim of this study was to assess whether chronic alcohol misuse affects N-methyl-d-aspartate (NMDA) receptor subunit concentrations in human cases, and whether male and female subjects respond differently. METHODS Real-time RT-PCR normalized to GAPDH was used to assay NR1, NR2A and NR2B subunit mRNA in superior frontal (SFC) and primary motor (PMC) cortex tissue obtained at autopsy from chronic alcoholics with and without comorbid cirrhosis of the liver, and from matched controls… CONTINUE READING
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