Sex differences in 3,4-methylenedioxymethamphetamine (MDMA; ecstasy)-induced cytochrome P450 2D6 inhibition in humans.

@article{YuberoLahoz2011SexDI,
  title={Sex differences in 3,4-methylenedioxymethamphetamine (MDMA; ecstasy)-induced cytochrome P450 2D6 inhibition in humans.},
  author={Samanta Yubero-Lahoz and Ricardo Pardo and Mag{\'i} Farr{\'e} and Brian O'Mahony and Marta Torrens and Cristina Mustata and C P{\'e}rez-Ma{\~n}{\'a} and Marcel li Carb{\'o} and Rafael de la Torre},
  journal={Clinical pharmacokinetics},
  year={2011},
  volume={50 5},
  pages={319-29}
}
BACKGROUND AND OBJECTIVE 3,4-Methylenedioxymethamphetamine (MDMA; ecstasy) is a ring-substituted amphetamine widely used for recreational purposes. MDMA is predominantly O-demethylenated in humans by cytochrome P450 (CYP) 2D6 and is also a potent mechanism-based inhibitor of the enzyme. This study assessed the inhibition and recovery half-life of CYP2D6 and CYP3A4 activity in female subjects by administering the probe drug dextromethorphan before and repeatedly after MDMA administration. These… CONTINUE READING
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