Sex differences and phase of light cycle modify chronic stress effects on anxiety and depressive-like behavior

@article{Huynh2011SexDA,
  title={Sex differences and phase of light cycle modify chronic stress effects on anxiety and depressive-like behavior},
  author={Thu N Huynh and Amanda M Krigbaum and Jeffery J. Hanna and Cheryl D. Conrad},
  journal={Behavioural Brain Research},
  year={2011},
  volume={222},
  pages={212-222}
}
The experiment examined whether sex differences and the phase of the light cycle modified how chronic restraint stress influenced anxiety and depressive-like behavior. Rats were restrained (6h/d/21d) and tested on the open field (OF), elevated plus maze (EPM), forced swim test (FST), and sucrose preference (SP) test. Chronic stress increased anxiety in both males and females in different tasks during the dark phase, but not in the light phase. When tested during the dark, chronic stress… CONTINUE READING

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