Sex differences, learning flexibility, and striatal dopamine D1 and D2 following adolescent drug exposure in rats

@article{Izquierdo2016SexDL,
  title={Sex differences, learning flexibility, and striatal dopamine D1 and D2 following adolescent drug exposure in rats},
  author={Alicia Izquierdo and Hilda Pozos and Adrianna De La Torre and Simone Deshields and James A. Cevallos and Jonathan Rodriguez and Alexandra Stolyarova},
  journal={Behavioural Brain Research},
  year={2016},
  volume={308},
  pages={104-114}
}
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References

SHOWING 1-10 OF 73 REFERENCES

Methylphenidate Administration to Adolescent Rats Determines Plastic Changes on Reward-Related Behavior and Striatal Gene Expression

The data indicate short-term changes in neural plasticity, suggested by modulation of expression of key genes, and functional changes in striatal circuits, which might in turn trigger enduring changes responsible for the adult neurobehavioral profile.

Long-term effects of exposure to methamphetamine in adolescent rats.

Fluoxetine Exposure during Adolescence Alters Responses to Aversive Stimuli in Adulthood

Exposure to FLX during adolescence modulates responsiveness to emotion-eliciting stimuli in adulthood, at least partially, via long-lasting adaptations in ERK-related signaling within the VTA, which further delineate the role ERK plays in regulating mood-related behaviors across the lifespan.

Effects of chronic oral methylphenidate on cocaine self-administration and striatal dopamine D2 receptors in rodents

Methylphenidate Administration to Juvenile Rats Alters Brain Areas Involved in Cognition, Motivated Behaviors, Appetite, and Stress

It is suggested that developmental exposure to high therapeutic doses of MPH has short-term effects on select neurotransmitters in brain regions involved in motivated behaviors, cognition, appetite, and stress.

Methylphenidate and MDMA adolescent exposure in mice: long-lasting consequences on cocaine-induced reward and psychomotor stimulation in adulthood

Chronic methylphenidate treatment during adolescence increases anxiety-related behaviors and ethanol drinking in adult spontaneously hypertensive rats

It is suggested that MPD treatment during adolescence induces persistent changes on emotionality and ethanol consumption in SHRs, but these effects depend on the sex and behavioral test used.

Fluoxetine exposure during adolescence increases preference for cocaine in adulthood

Adolescent exposure to FLX increases sensitivity to the rewarding properties of cocaine, later in life, according to age-matched saline pretreated controls.

Neurobehavioral adaptations to methylphenidate: The issue of early adolescent exposure

Fluoxetine Exerts Age-Dependent Effects on Behavior and Amygdala Neuroplasticity in the Rat

It is shown that fluoxetine exerts both harmful and beneficial age-dependent effects on depressive behavior, body weight and wakefulness, which may relate, in part, to differential fluoxettine-induced neuroplasticity in the amygdala.
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