Sex difference in the phosphorylation of cAMP response element binding protein (CREB) in neonatal rat brain.

@article{Auger2001SexDI,
  title={Sex difference in the phosphorylation of cAMP response element binding protein (CREB) in neonatal rat brain.},
  author={Anthony P. Auger and D P Hexter and Margaret M McCarthy},
  journal={Brain research},
  year={2001},
  volume={890 1},
  pages={110-7}
}
On the day of birth, a surge in testicular testosterone release in male rats is critical for sexual differentiation of the brain. Steroid hormones function by binding to intracellular steroid receptors and altering gene expression; however, little is known about the signal transduction pathways altered as a consequence of steroid hormone action in developing brain. We investigated whether the increase in testosterone at birth alters the phosphorylation of CREB, a major signal transduction… CONTINUE READING

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