Sex difference in the association of the angiotensin converting enzyme I/D polymorphism and body mass index.

@article{Wacker2008SexDI,
  title={Sex difference in the association of the angiotensin converting enzyme I/D polymorphism and body mass index.},
  author={Michael J. Wacker and Michael P. Godard and Everlee H McCabe and Joseph Donnelly and John K. Kelly},
  journal={Medical science monitor : international medical journal of experimental and clinical research},
  year={2008},
  volume={14 7},
  pages={
          CR353-7
        }
}
BACKGROUND Angiotensin converting enzyme (ACE) catayzes the formation of angiotensin I to angiotensin II. A polymorphism has been identified in intron 16 in which a 287 base-pair alu sequence was found to be present (insertion or I) or absent (deletion or D) in the population. ACE and the components of the renin-angiotensin system are expressed in adipose tissue and therefore the I/D polymorphism within ACE may be associated with obesity. MATERIAL/METHODS This study involved genotyping two… CONTINUE READING

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