Sex difference in the action of activin-A on cell proliferation of differentiating rat gonad.

@article{Kaipia1994SexDI,
  title={Sex difference in the action of activin-A on cell proliferation of differentiating rat gonad.},
  author={Antti Kaipia and Jorma Toppari and I lpo Huhtaniemi and Jorma Paranko},
  journal={Endocrinology},
  year={1994},
  volume={134 5},
  pages={2165-70}
}
The effect of recombinant bovine activin-A on DNA synthesis in fetal rat gonads and mesonephroi was studied in vitro by using [3H]thymidine autoradiography to evaluate the role of activin in the regulation of gonadal development. mRNA levels of inhibin-beta A and -beta B, activin receptor II and IIB (ActRII and ActRIIB), and follistatin were studied by Northern hybridization in the fetal rat gonads and mesonephroi. Activin stimulated thymidine incorporation in ovaries and female mesonephroi on… CONTINUE READING