Sex determination involves synergistic action of SRY and SF1 on a specific Sox9 enhancer

@article{Sekido2008SexDI,
  title={Sex determination involves synergistic action of SRY and SF1 on a specific Sox9 enhancer},
  author={Ryohei Sekido and Robin Lovell-Badge},
  journal={Nature},
  year={2008},
  volume={453},
  pages={930-934}
}
The mammalian Y chromosome acts as a dominant male determinant as a result of the action of a single gene, Sry, whose role in sex determination is to initiate testis rather than ovary development from early bipotential gonads. It does so by triggering the differentiation of Sertoli cells from supporting cell precursors, which would otherwise give follicle cells. The related autosomal gene Sox9 is also known from loss-of-function mutations in mice and humans to be essential for Sertoli cell… CONTINUE READING
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