Sex determination in mammals — Before and after the evolution of SRY

@article{Wallis2008SexDI,
  title={Sex determination in mammals — Before and after the evolution of SRY},
  author={M. C. Wallis and Paul D. Waters and Jennifer A. Marshall Graves},
  journal={Cellular and Molecular Life Sciences},
  year={2008},
  volume={65},
  pages={3182-3195}
}
Abstract.Therian mammals (marsupials and placentals) have an XX female: XY male sex chromosome system, which is homologous to autosomes in other vertebrates. The testis-determining gene, SRY, is conserved on the Y throughout therians, but is absent in other vertebrates, suggesting that the mammal system evolved about 310 million years ago (MYA). However, recent work on the basal monotreme mammals has completely changed our conception of how and when this change occurred. Platypus and echidna… Expand
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References

SHOWING 1-10 OF 116 REFERENCES
Sex determination in platypus and echidna: autosomal location of SOX3 confirms the absence of SRY from monotremes
TLDR
The autosomal localization of SOX3 in monotreme mammals, as well as non-mammal vertebrates, implies that SRY is absent in Prototheria and evolved later in the therian lineage 210-180 million years ago, implying sex determination in platypus and echidna must therefore depend on another male-determining gene(s) on the Y chromosomes, or on the different dosage of a gene on the X chromosomes. Expand
Bird-like sex chromosomes of platypus imply recent origin of mammal sex chromosomes.
In therian mammals (placentals and marsupials), sex is determined by an XX female: XY male system, in which a gene (SRY) on the Y affects male determination. There is no equivalent in other amniotes,Expand
The multiple sex chromosomes of platypus and echidna are not completely identical and several share homology with the avian Z
TLDR
A comparative study of platypus and echidna by chromosome painting and comparative gene mapping shows that monotremes have a unique XY sex chromosome system that shares some homology with the avian Z. Expand
Autosomal location of genes from the conserved mammalian X in the platypus (Ornithorhynchus anatinus): implications for mammalian sex chromosome evolution
TLDR
It is demonstrated that part of the therian X chromosome was lost from the platypus X1 to an autosome, which included genes flanking the XIST locus, and also genes with Y-linked homologues that are important to male reproduction in therians. Expand
Evolution of the human X – a smart and sexy chromosome that controls speciation and development
TLDR
The origin of the human X, and the evolution of dosage compensation and gene content, is discussed, in the light of recent demonstrations that particular functions in sex and reproduction and cognition have accumulated on it. Expand
Mammalian sex--Origin and evolution of the Y chromosome and SRY.
TLDR
The organization and evolution of the sex chromosomes across a broad range of mammals is discussed, and how the Y chromosome, and SRY, evolved is speculated on. Expand
Evolution: Conservation of a sex-determining gene
TLDR
It is shown that a gene implicated in human testis differentiation, DMRT1, has a gonad-specific and sexually dimorphic expression profile during embryogenesis in mammals, birds and a reptile (Alligator mississippiensis). Expand
Sequences homologous to ZFY, a candidate human sex-determining gene, are autosomal in marsupials
TLDR
Using the ZFY probe, it is found that the Zfy homologous sequences are not on either the X or the Y chromosome in marsupials, but map to the auto-somes, which implies ZFY is not the primary sex-determining gene in mars upials. Expand
Evolution of sex determination and the Y chromosome: SRY-related sequences in marsupials
TLDR
Comparisons of eutherian and metatherian Y-located SRY sequences suggest rapid evolution of these genes, especially outside the region encoding the DNA-binding HMG box. Expand
Interactions between SRY and SOX genes in mammalian sex determination.
  • J. Graves
  • Biology, Medicine
  • BioEssays : news and reviews in molecular, cellular and developmental biology
  • 1998
TLDR
This hypothesis makes testable predictions of the phenotypes of XX and XY individuals with deficiencies or overproduction of any of the three genes, and is able to account for the difficult cases of XX(SRY-) males and transdifferentiation in the absence of SRY. Expand
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