Sex determination and gonadal development in mammals.

  title={Sex determination and gonadal development in mammals.},
  author={Dagmar Wilhelm and S Palmer and Peter Koopman},
  journal={Physiological reviews},
  volume={87 1},
Arguably the most defining moment in our lives is fertilization, the point at which we inherit either an X or a Y chromosome from our father. The profoundly different journeys of male and female life are thus decided by a genetic coin toss. These differences begin to unfold during fetal development, when the Y-chromosomal Sry ("sex-determining region Y") gene is activated in males and acts as a switch that diverts the fate of the undifferentiated gonadal primordia, the genital ridges, towards… 

Sex Determination and Sex Differentiation

The mechanisms that contribute to female and male sex determination and gonadal development are discussed, in an attempt to understand the basics of human sex.

Sexual development of the soma in the mouse.

Genetic mechanisms underlying male sex determination in mammals

  • R. Piprek
  • Biology
    Journal of Applied Genetics
  • 2010
In the absence of Sry, the predomination of the female pathway results in the realization of a robust genetic program that drives ovarian differentiation.

Genetic mechanisms underlying male sex determination in mammals

Surprisingly, splicing, nuclear transport, and extramatrix proteins may be involved in sex determination.

Sex determination and maintenance: the role of DMRT1 and FOXL2

Evidence that it is possible for the gonadal sex phenotype to be switched even in adulthood is provided, and two key genes, doublesex and mad-3 related transcription factor 1 and forkhead box L2 (Foxl2), function in a Yin and Yang relationship to maintain the fates of testes or ovaries in adult mammals, are shown.

Cis-Regulatory Control of Mammalian Sex Determination

Recent advances in the understanding of non-coding, cis-acting gene regulatory elements are highlighted and how they may control transcriptional programmes that underpin sex determination in the context of the 3-dimensional folding of chromatin are discussed.

Explorer Germ cell sex determination in mammals

The evidence for the existence of meiosis-inducing and meiosis -preventing substances in the developing gonad is reviewed, and the possibility that some of the reported effects on germ cell development may be indirect consequences of impairing sexual differentiation of gonadal somatic cells or germ cell survival is discussed.



Screening for novel mammalian sex-determining genes using expression cloning and microarray approaches

A number of genes have been shown by Screening for Novel Mammalian Sex-Determining Genes using Expression Cloning and Microarray Approaches and its mode of action is still not clear and its target genes are yet to be identified.

Testis determination requires insulin receptor family function in mice

It is shown that the insulin receptor tyrosine kinase family, comprising Ir, Igf1r and Irr, is required for the appearance of male gonads and thus for male sexual differentiation.

Expression of a candidate sex-determining gene during mouse testis differentiation

The observations strongly support a primary role for Sry in mouse sex determination, and further the involvement of this gene, Sry, in testis development, which is studied in detail.

A new look at the mechanisms controlling sex differentiation in mammals.

  • A. Jost
  • Biology
    The Johns Hopkins medical journal
  • 1972
The testis appears to be the sex differentiator in the fetus and some factor in the freemartin gonad both inhibits the growth of the outer part of the gonads and induces the retrogression of the upper Mullerian ducts.

The LIM homeobox gene Lhx9 is essential for mouse gonad formation

It is shown that transcripts of the LIM homeobox gene Lhx9 are present in urogenital ridges of mice at embryonic day 9.5; later they localize to the interstitial region as morphological differentiation occurs, indicating that LHX9 mutations may underlie certain forms of isolated gonadal agenesis in humans.

Male-specific cell migration into the developing gonad

Development of the mammalian gonad: The fate of the supporting cell lineage

  • A. McLaren
  • Biology
    BioEssays : news and reviews in molecular, cellular and developmental biology
  • 1991
Sex determination in mammals is mediated via the supporting cell lineage in the fetal gonad, where supporting cells in which the male‐determining gene is expressed in a timely manner differentiate as pre‐Sertoli cells; given sufficient such cells, testis cords form and development proceeds in a male direction.