Sex determination and SRY: down to a wink and a nudge?

  title={Sex determination and SRY: down to a wink and a nudge?},
  author={Ryohei Sekido and Robin Lovell-Badge},
  journal={Trends in genetics : TIG},
  volume={25 1},
Sex-determining region Y (Sry) is the crucial gene that initiates male sex determination in most mammals. Although several components of the pathway regulating sexual differentiation have been elucidated, the mechanism of Sry action within this was unclear. However, recent discoveries in cellular, genetic and molecular aspects of gonad development are shedding light on the precise role of SRY in the regulation of Sox9, a crucial downstream target gene. SRY is thought to act synergistically with… CONTINUE READING
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