Sex-dependent compensated oxidative stress in the mouse liver upon deletion of catechol O-methyltransferase.

@article{TenorioLaranga2009SexdependentCO,
  title={Sex-dependent compensated oxidative stress in the mouse liver upon deletion of catechol O-methyltransferase.},
  author={Jofre Tenorio-Laranga and Pekka T. M{\"a}nnist{\"o} and Maria Karayiorgou and Joseph A Gogos and Juan Arturo Garc{\'i}a-Horsman},
  journal={Biochemical pharmacology},
  year={2009},
  volume={77 9},
  pages={1541-52}
}
Catechol-O-methyl transferase (COMT) methylates catechols, such as L-dopa and dopamine, and COMT deficient mice show dramatic shifts in the metabolite levels of catechols. Increase in catechol metabolite levels can, in principle, lead to oxidative stress but no indices of oxidative stress have been reported in COMT-knockout (KO) mice [Forsberg MM, Juvonen RO, Helisalmi P, Leppanen J, Gogos JA, Karayiorgou M, et al. Lack of increased oxidative stress in catechol-O-methyltransferase (COMT… CONTINUE READING