Sex-dependent association between erythrocyte n-3 PUFA and type 2 diabetes in older overweight people.

@article{Abbott2016SexdependentAB,
  title={Sex-dependent association between erythrocyte n-3 PUFA and type 2 diabetes in older overweight people.},
  author={Kylie A Abbott and Martin Veysey and Mark D. Lucock and Suzanne H Niblett and Katrina King and Tracy L. Burrows and Manohar L. Garg},
  journal={The British journal of nutrition},
  year={2016},
  volume={115 8},
  pages={
          1379-86
        }
}
The association between n-3 PUFA intake and type 2 diabetes (T2D) is unclear, and studies relating objective biomarkers of n-3 PUFA consumption to diabetic status remain limited. The aim of this study was to determine whether erythrocyte n-3 PUFA levels (n-3 index; n-3I) are associated with T2D in a cohort of older adults (n 608). To achieve this, the n-3I (erythrocyte %EPA+%DHA) was determined by GC and associated with fasting blood glucose; HbA1c; and plasma insulin. Insulin resistance (IR… 
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References

SHOWING 1-10 OF 39 REFERENCES
Association of erythrocyte membrane fatty acids with changes in glycemia and risk of type 2 diabetes.
TLDR
EMFAs and their ratios are associated longitudinally with changes in glycemia and the risk of type 2 diabetes.
Plasma omega-3 fatty acids and incident diabetes in older adults.
TLDR
With the use of objective biomarkers, long-chain n-3 FAs and ALA were not associated with a higher incidence of diabetes.
Fish intake, erythrocyte n-3 fatty acid status and metabolic health in Danish adolescent girls and boys
TLDR
The present study showed the expected association between fish intake and RBC-DHA, which in contrast to expectations tended to be associated with a poorer metabolic profile.
Omega-3 fatty acids and incident type 2 diabetes: a systematic review and meta-analysis
TLDR
The overall pooled findings do not support either major harms or benefits of fish/seafood or EPA+DHA on development of DM, and suggest that ALA may be associated with modestly lower risk.
Association of fish and n-3 fatty acid intake with the risk of type 2 diabetes: a meta-analysis of prospective studies
TLDR
Evidence from observational studies suggests that the intake of both fish and n-3 fatty acids might be weakly positively associated with the T2DM risk, and further studies are needed to confirm these results.
Omega-3 Fatty Acids Improve Glucose Metabolism without Effects on Obesity Values and Serum Visfatin Levels in Women with Polycystic Ovary Syndrome
TLDR
Omega-3 fatty acids improved insulin sensitivity in PCOS patients, and this beneficial effect was not associated with alteration in anthropometric measurements and serum visfatin levels.
Erythrocyte n-3 fatty acids and metabolic syndrome in middle-aged and older Chinese.
TLDR
Higher concentrations of erythrocyte DHA were associated with lower odds of MetS, whereas higher concentrations of ALA wereassociated with increased odds among middle-aged and older Chinese.
Omega-3 index, obesity and insulin resistance in children.
  • T. Burrows, C. Collins, M. Garg
  • Medicine
    International journal of pediatric obesity : IJPO : an official journal of the International Association for the Study of Obesity
  • 2011
TLDR
The observed association between the Omega-3 index, weight status and insulin resistance in children highlights the importance of omega-3 fatty acids in the prevention of obesity-related chronic diseases in later life.
Omega-3 Index Correlates with Healthier Food Consumption in Adolescents and with Reduced Cardiovascular Disease Risk Factors in Adolescent Boys
TLDR
The Omega-3 Index, a measure of long-chain omega-3 fats in red blood cell membranes, predicts heart disease mortality in adults, but its association with cardiovascular risk factors in younger populations is unknown, and it warrants further investigation in the adolescent population.
ω-3 polyunsaturated fatty acid supplementation does not influence body composition, insulin resistance, and lipemia in women with type 2 diabetes and obesity.
TLDR
A high dose of ω-3 PUFA can reduce insulin resistance and insulin sensitivity, and a lower dose positively influenced body composition and lipid metabolism.
...
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