Sex chromosomes and brain gender

@article{Arnold2004SexCA,
  title={Sex chromosomes and brain gender},
  author={Arthur P. Arnold},
  journal={Nature Reviews Neuroscience},
  year={2004},
  volume={5},
  pages={701-708}
}
  • A. Arnold
  • Published 1 September 2004
  • Biology, Psychology
  • Nature Reviews Neuroscience
In birds and mammals, differences in development between the sexes arise from the differential actions of genes that are encoded on the sex chromosomes. These genes are differentially represented in the cells of males and females, and have been selected for sex-specific roles. The brain is a sexually dimorphic organ and is also shaped by sex-specific selection pressures. Genes on the sex chromosomes probably determine the gender (sexually dimorphic phenotype) of the brain in two ways: by acting… 
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References

SHOWING 1-10 OF 134 REFERENCES
Sex chromosome genes directly affect brain sexual differentiation
TLDR
Using mice in which the genetic sex of the brain was independent of gonadal phenotype, it was found that XY and XX brain cells differed in phenotype, indicating that a brain cell's complement of sex chromosomes may contribute to its sexual differentiation.
Are XX and XY brain cells intrinsically different?
Neural, not gonadal, origin of brain sex differences in a gynandromorphic finch
  • R. Agate, W. Grisham, A. Arnold
  • Biology, Psychology
    Proceedings of the National Academy of Sciences of the United States of America
  • 2003
TLDR
Analysis of the sexual phenotype of the brain of a rare gynandromorphic finch in which the right half of the head was genetically male and the left half genetically female indicates that the genetic sex of brain cells contributes to the process of sexual differentiation.
The gender of the voice within: the neural origin of sex differences in the brain
  • A. Arnold
  • Biology, Psychology
    Current Opinion in Neurobiology
  • 2003
A Model System for Study of Sex Chromosome Effects on Sexually Dimorphic Neural and Behavioral Traits
TLDR
The results show that sex chromosome genes contribute directly to the development of a sex difference in the brain.
Sex differences in sex chromosome gene expression in mouse brain.
TLDR
Three X-Y gene pairs appeared to be differentially regulated (expressed in brain in a different age- or tissue-dependent pattern), and hence may not be functionally equivalent and suggest several mechanisms by which these genes may participate in sex differences in brain development and function.
Sexual Differentiation of the Vertebrate Brain: Principles and Mechanisms
TLDR
There is ample evidence of sexual dimorphism in the human brain, as sex differences in behavior would require, but there has not yet been any definitive proof that steroids acting early in development directly masculinize the humanbrain.
SEX CHROMOSOMES AND THE EVOLUTION OF SEXUAL DIMORPHISM
  • W. Rice
  • Biology
    Evolution; international journal of organic evolution
  • 1984
TLDR
The idea that sex chromosomes also play an important role in the evolution of sexually dimorphic traits is evaluated and how the sex chromosomes can facilitate this evolution is suggested.
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