Sex chromosome aneuploidy and aging.

  title={Sex chromosome aneuploidy and aging.},
  author={Jeffrey F. Stone and Avery A. Sandberg},
  journal={Mutation research},
  volume={338 1-6},
Loss of an X chromosome in females and of the Y chromosome in males are phenomena associated with aging. X chromosome loss occurs in and may be limited to PHA stimulated peripheral lymphocytes. In males, the loss of the Y is most evident in bone marrow cells, but also occurs to a lesser extent in PHA stimulated peripheral lymphocytes. X chromosome loss is associated with premature centromere division leading to anaphase lag and elimination in micronuclei. The mechanism of Y chromosome loss has… CONTINUE READING

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