Sex-based transmural differences in cardiac repolarization and ionic-current properties in canine left ventricles.

@article{Xiao2006SexbasedTD,
  title={Sex-based transmural differences in cardiac repolarization and ionic-current properties in canine left ventricles.},
  author={Ling Xiao and Liming Zhang and Wei Han and Zhiguo Wang and Stanley Nattel},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2006},
  volume={291 2},
  pages={H570-80}
}
The female sex is associated with longer electrocardiographic QT intervals and increased proarrhythmic risks of QT-prolonging drugs. This study examined the hypothesis that sex differences in repolarization may be associated with differential transmural ion-current distribution. Whole cell patch-clamp and current-clamp were used to study ionic currents and action potentials (APs) in isolated canine left ventricular cells from epicardium, midmyocardium, and endocardium. No sex differences in AP… CONTINUE READING